Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2015  |  Volume : 28  |  Issue : 2  |  Page : 514-520

Tenascin-C expression in lichen planus


1 Department of Dermatology, Venereology and Andrology, Menoufia University, Shebein Elkom, Egypt
2 Department of Pathology, Faculty of Medicine, Menoufia University, Shebein Elkom, Egypt
3 Mehalla General Hospital, Mehalla, Gharbia, Egypt

Correspondence Address:
Hany Y Metawea
Mehalla General Hospital, 16 Gamal Abd El Naser st, Manshiet Al Bakry, Mehalla, Gharbia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.163911

Rights and Permissions

Objectives The aims of this study were to evaluate the immunohistochemical expression of tenascin-C (TN-C) in lichen planus (LP) and to highlight its hypothesized role in the etiopathogenesis of this disease entity. Background LP is an inflammatory disease of the skin and the mucous membrane, the exact etiology of which is not known; however, multiple theories have been proposed. TN-C is an extracellular matrix glycoprotein that plays different roles, mediating both inflammatory and fibrotic processes. However, little information about its role in LP exists. Patients and methods Thirty patients with LP and 10 age-matched and sex-matched volunteers as controls were included. They were subjected to complete history taking, and general and dermatological examination. Skin biopsies were taken from the lesional skin of LP patients and the normal skin of controls. Biopsies were subjected to routine hematoxylin and eosin staining and immunostaining for TN-C. Results Forty-three percent of LP cases showed epidermal expression, whereas most of the cases (77%) showed a positive dermal expression. Dermal expression of TN-C is significantly elevated in cases than in controls (P = 0.01). Positive correlations between the dermal expression of TN-C and the intensity of lymphocytic infiltrate and the severity of pruritus were demonstrated. Dermal TN-C expression is significantly elevated in hypertrophic LP cases and in cases with leg lesions. Epidermal expression of TN-C showed no significant correlation with any of the clinical or pathological features. Conclusion Prominent TN-C expression in LP lesions magnifies its role in the pathogenesis of this disease.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed689    
    Printed10    
    Emailed0    
    PDF Downloaded72    
    Comments [Add]    

Recommend this journal