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REVIEW ARTICLE
Year : 2014  |  Volume : 27  |  Issue : 4  |  Page : 683-685

Role of intercellular adhesion molecule 1 in development of diabetes and diabetic nephropathy


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Artificial Kidney Department, Kom Hamada Hospital, Kom Hamada, Egypt

Correspondence Address:
Amal Mohamed Salah Eldein Ahmed Anan
Gamaa Elfolly street, Shobra el Namla, Tanta, Gharbiya Governate
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.149673

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Objective The present work aimed to discuss the association between intercellular adhesion molecule 1 (ICAM1) and development of both diabetes mellitus and diabetic nephropathy. Data sources They included English language citation in the last 20 years from the database of abstracts of reviews from 2005 to 2013 updates from expert reviews and literatures surveillance. Study selection Systematic reviews that addressed ICAM1 and studies that addressed the association of ICAM1 with development of both diabetes mellitus and diabetic nephropathy and mechanism of the benefit of inhibition of ICAM1 in treatment of diabetes mellitus and diabetic nephropathy were included. Data extraction Special search was performed at midline in the title of papers; all articles including review articles in the last 20 years were reviewed. In addition, a special search was performed at specific databases including science direct and genetic association studies of ICAM1 gene in diabetes mellitus and diabetic nephropathy used in midline search, and also studies in the last 20 years were included. Data synthesis The researcher reviewed each study independently and rebuilt obtained data in his own language according to his needs to know the role of ICAM1 in development of both diabetes mellitus and diabetic nephropathy through the article. Conclusion ICAM1 is most likely a useful biomarker for prediction of endothelial dysfunction in diabetes and diabetic nephropathy.


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