Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 27  |  Issue : 4  |  Page : 677-682

Comparative study of the effect of high-flux versus low-flux dialysis membranes on metabolic abnormalities in chronic hemodialysis patients


1 Department of Internal Medicine, Faculty of Medicine, Menoufiya University, Al-Menoufiya, Egypt
2 Department of Nephrology, Benha Teaching Hospital, Benha, Egypt

Correspondence Address:
Abd El Samad Sobhy Abou El Nasr
Garawan, El Bagour, Al-Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.149667

Rights and Permissions

Objective The aim of the study was to compare the effect of permeability of low-flux versus high-flux dialysis membranes on control of metabolic abnormalities in chronic hemodialysis patients. Background End-stage renal disease is associated with multiple physiological and metabolic disturbances, including hypertension, anemia, hyperparathyroidism, dyslipidemia, malnutrition, and other serious problems that markedly and negatively affect prognosis and the quality of life of uremic patients. New dialyzers have large pores and they are more compatible than pure cellulose membranes; thus, they provoke less inflammatory reaction and are more efficient in removal of uremic toxins. Materials and methods Forty adult patients on regular hemodialysis were enrolled in a prospective study. Low-flux polysulfone membranes were used for at least 6 months and then patients were switched to use high-flux polysulfone membranes for 1 month. Serum electrolytes and intact parathyroid hormone (PTH) before and after dialysis were compared before and after changes in dialysis membrane. Results At the end of the 1-month use of high-flux filters, a highly significant increase in the mean of hemoglobin levels from 9.50 ± 1.08 to 10.29 ± 1.04 (P = 0.001) was evident. Postdialysis mean arterial blood pressure decreased significantly after use of high-flux dialysis (P = 0.002). There were highly significant decreases in predialysis blood urea nitrogen, phosphorus, sodium, and potassium after the use of high-flux filters. Predialysis intact PTH level (415.96 ± 226.72 ng/dl) showed a significant decline (P < 0.05) compared with the predialysis intact PTH (312.28 ± 191.98 ng/dl) with low-flux membranes. Conclusion High-flux dialysis membranes are more efficient in control of metabolic abnormalities in chronic hemodialysis patients than low-flux membranes.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1821    
    Printed13    
    Emailed0    
    PDF Downloaded194    
    Comments [Add]    
    Cited by others 1    

Recommend this journal