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ORIGINAL ARTICLE
Year : 2014  |  Volume : 27  |  Issue : 3  |  Page : 562-565

Assessment of the immune response to hepatitis B virus vaccine as a major factor in the prevention of hepatitis B infection


1 Department of Tropical Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Clinicl Pathology, Faculty of Medicine, Menoufia University, Menoufia, Egypt
3 Department of Tropical Medicine, Ministry of Health, Egypt

Correspondence Address:
Ahmed Ali El-Sersy
Elhamoul, Menof, Menoufia
Egypt
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.145513

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Objective The aim of the work was to study the effect of hepatitis B virus (HBV) vaccine as a major factor in the prevention of HBV infection. Background Measuring the level of hepatitis B surface antibodies in different age groups to determine the time of fading of hepatitis B surface antibodies and whether there is a need for a booster dose or not. Patients and methods Ninety random persons selected among those attending Menoufia Fever Hospital, Menoufia governorate, who were previously vaccinated with HBV vaccine, were classified into three groups. Results Significantly, the seroprotection rate among vaccinated children up to 5 years was 70.0%, with a mean concentration of HBsAb of 139 mIU/ml; of them, 40.0% were over-responders (>100 mIU/ml), 30% were adequate responders (10-100 mIU/ml), and 30.0% were nonresponders. In the second group, the mean concentration of HBsAb was 70 mIU/ml, wherein 43.3% were considered responders; of them, 13.3% were over-responders, 30% were adequate responders, and 56.7% were nonresponders (HBsAb <10 mIU/ml). The HCW of the third group shows that the mean concentration of HBsAb was 639 mIU/ml; 20.0% were adequate responders and 80.0% were over-responders. Conclusion The HBV vaccine has a major effect on the prophylaxis and the prevention of HBV infection. The HBV vaccine efficacy decreased with increasing age up to 18 years. There was 100% response in healthcare workers 5 years after vaccination.


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