Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2014  |  Volume : 27  |  Issue : 2  |  Page : 458-464

Study of microvascular complications of chronic hepatitis C virus in nondiabetic patients


1 Department of Internal Medicine, Faculty of Medicine, Menoufia University, Menoufia, Egypt
2 Department of Internal Medicine, Shebin El-Kom Educational Hospital, Menoufia, Egypt

Correspondence Address:
Walaa Khalil Mohamed Ali Sultan
MBBCh, Arab EL-Raml, Qwesna, Menoufia
Egypt
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1110-2098.141727

Rights and Permissions

Objective To study the relationship between chronic hepatitis C infection and microvascular complications in nondiabetic individuals. Background Several extrahepatic manifestations have been reported in the natural history of hepatitis C virus (HCV) infection. Further, extrahepatic manifestation syndromes could represent the first signal of an HCV infection, as many patients show no hepatic symptoms. As known microvascular complications of diabetes include neuropathy, nephropathy and retinopathy, this study was conducted to evaluate the effect of chronic HCV infection on microvascular complications in nondiabetic patients. Subjects and methods Fifty patients with chronic hepatitis C infection were enrolled. All were subjected to full clinical assessment including routine blood tests, fasting and 2 h postprandial blood glucose, HbA1c, HCV-RNA PCR, urinary albumin concentration indicating the presence of microalbuminuria, liver biopsy and fundus examination. Results Microalbuminuria was diagnosed in five patients (10%) with chronic hepatitis C, whereas 15 patients (30%) had peripheral neuropathy as diagnosed by clinical examination; no retinopathy was diagnosed in these patients. Peripheral neuropathy correlated with age, HCV viremia and stages of liver biopsy. Conclusion Patients with chronic HCV infection had a high incidence of developing microalbuminuria (10%), a very high incidence of developing peripheral neuropathy (30%) and no incidence of developing retinopathy (zero%). Age, the HCV-RNA level and liver fibrosis are prominent risk factors for the occurrence of peripheral neuropathy in chronic HCV-infected patients.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1110    
    Printed9    
    Emailed0    
    PDF Downloaded106    
    Comments [Add]    

Recommend this journal